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The principal cytochrome P450 isoenzyme involved seems to get CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Close to 85% of an oral dose seems inside the urine within just 24 hrs of administration, most since the glucuronide conjugate, with tiny quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity facts.Zidovudine  T